20 January, 2019

#amyloidosisJC 1/23/19: LECT2 Amyloidosis

#amyloidosisJC resumes this week on a new night: Wednesday night (Jan 23, 2019 at 8 pm EST). 

Short notice and a short but important article describing a series of patients with a relatively recently recognized subtype of amyloidosis: ALect2. 

Here is a link to the full text of the article: 


For anyone unable to access the article via that link, email me at zonderj@gmail.com and I can send you the pdf. 

The article we are reviewing this week discusses a series of 130 patients with hepatic #amyloidosis analyzed with tandem mass spectrometry at the Mayo Clinic. 

Key Points:

  • The most common form of hepatic amyloidosis was AL (light chain) subtype. Alect2 also commonly affects the kidneys. 
  • Leukocyte cell-derived chemotaxin 2 associated amyloidosis (ALect2) was next most common (25% of analyzed cases).
  • No definite amyloid-associated LECT2 gene mutation has been identified, but 10 of 10 sequenced patients in another report were homozygous for the G nucleotide in a non-synonymous SNP amongst people of Mexican heritage. 

We'll talk about Alect2 and other forms of hepatic and renal amyloidosis this Wednesday - join us!